High levels of interleukin-1 in patients with endemic pemphigus foliaceus.

نویسندگان

  • Denise Bertulucci Rocha-Rodrigues
  • Giovana Paschoini
  • Sanivia Aparecida Lima Pereira
  • Marlene Antonia dos Reis
  • Vicente de Paula Antunes Teixeira
  • Virmondes Rodrigues Júnior
چکیده

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.

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عنوان ژورنال:
  • Clinical and diagnostic laboratory immunology

دوره 10 5  شماره 

صفحات  -

تاریخ انتشار 2003